Molecular profile of 5-fluorouracil pathway genes in colorectal carcinoma
نویسندگان
چکیده
منابع مشابه
Variance in the expression of 5-Fluorouracil pathway genes in colorectal cancer.
Although colorectal cancer has the third highest cancer mortality rate, the treatment remains far from optimized with patients showing variable responses to standard treatment. Molecular differences in pharmacologically relevant genes may contribute to the variability in response. This study used Taqman PCR to investigate the expression of 24 5-fluorouracil (5-FU) pathway genes in colorectal ca...
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TGF-β pathway is generally associated with the processes of metastasis, angiogenesis and EMT in cancer. Very little is known, however, about the role of TGF-β in cancer drug resistance. In this work, we show a specific activation of the TGF-β pathway in consequence of chemotherapeutic treatment in in vivo and in vitro models of colorectal carcinoma. 5-Fluorouracil (5FU) was able to stimulate th...
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colorectal cancer is an emerging public health problem in indonesia and currently ranks among the three highest cancers. lack of a colonoscopy screening and lifestyle changes might contribute to it. in the last few decades, there is an increasing interest towards the contribution of genetic-environment interaction in colorectal carcinogenesis. some studies have indicated that crc might develop ...
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Following p.o. administration to rats bearing advanced colorectal carcinoma, Ftorafur (FT) is converted to 5-fluorouracil (FUra) by microsomal P450 in the liver. To optimize the therapeutic selectivity of the FUra generated from FT, three approaches were utilized: (a) inhibition of FUra degradation to dihydrofluorouracil by uracil as an alternative substrate for uracil reductase in the molar ra...
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ژورنال
عنوان ژورنال: BMC Cancer
سال: 2016
ISSN: 1471-2407
DOI: 10.1186/s12885-016-2826-8